Jennings returns to 49ers practice as game week arrives, with a fresh window to prove himself for an extension and a path to big early-season production if he stays healthy. Bourne’s visit adds a veteran wrinkle to SF’s depth chart, while Gage’s return keeps Week 1 WR plans fluid and could tilt target shares in Seattle. Purdy and Kittle anchor the offense, Moody’s lingering kicking questions loom, and the defense faces a Seahawks test that will expose SF’s plan for the run game and pass rush. The looming Bosa contract and Shanahan’s game management remain central to fantasy angles as SF aims to navigate health, division games, and a volatile Week 1 environment.

Mike McDonald and Seattle’s new-look scheme add complexity for SF’s approach, with Sam Darnold facing a blitz-heavy plan and SF’s young players expected to contribute early. In this landscape, Jennings’ Week 1 trajectory hinges on health and volume, while Purdy’s supporting cast—Kittle and McCaffrey—must carry pace. Sleeper’s nudges aside, the opener serves as a proving ground for how SF balances youth and vets over a 17-game horizon, especially given the division’s early tests.

Chase and Barkley anchor the early run, Bijan Robinson slides into a rare 1st-round slot, and Xavier Worthy plus Brian Thomas Jr. supply strong value at receiver later in the mock. George Kittle stands out as the premier TE, while Dak Prescott and Brock Purdy anchor a two-QB streaming mindset that favors late-round quarterback upside. The hosts dissect a hero-RB approach, weighing depth at WR and the subtle art of waiting on QB and TE, with matchups guiding every decision.

Overall, the takeaway is roster flexibility. The board rewarded savvy late picks and depth at wideout, with disciplined fades of positions that thin quickly. The mock emphasizes building compute-ready depth, then exploiting quality weekly matchups and breakout potential from mid-round targets to win in season-long fantasy.

Week 1 defense guidance centers on Seattle as a sleeper, Denver as an elite play, and Arizona as a solid Week 1 option, with San Francisco faded due to a bruised receiving corps. The Seahawks’ pass rush and reduced pressure from the 49ers’ weapons create upside in a risky opening slate. Arizona leans on youth and matchup leverage against New Orleans, while Denver’s elevation and a rookie QB make them a trusted, high-floor choice. Injuries and inexperience in Week 1 temper offenses across the board, so plan accordingly.

Detroit’s 2025 ceiling hinges on a healthy offensive line led by Frank Ragnow, with Taylor Decker and Penei Sewell anchoring the tackles and Sam LaPorta providing a mismatch threat at tight end. If the unit stays together, Gibbs and Montgomery can unlock a top-tier ground game and the duo of weapons around Jared Goff can keep the passing attack humming.

Across the NFC, Purdy’s connection with Ricky Pearsall could sharpen San Francisco’s aerial plan, even as Debo Samuel shifts to Washington. Kansas City remains formidable with Mahomes at the helm and an improved line. Cleveland’s QB situation is a wild card, while FanDuel’s Futures Day nods to the Giants as a sneaky breakout pick in the NFC.

Parsons' contract brinkmanship with Dallas and Jerry Jones' hardline stance anchors August's Cowboys chatter, with the agent angle adding a new wrinkle to the league's cap drama.

Seattle's run-first identity and SF's premium talent raise fantasy floors for JSN, Kupp, Kittle and Purdy, while Deebo Samuel and Brandon Aiyuk carve defined roles; a wave of potential trades and roster churn shapes Week 1 projections.